ZSX 3rd Quarter 2010 Newsletter

Greetings again from ZSX Medical as we bring you the fall edition of our newsletter. In this newsletter, we will provide an update as to our progress over the past few months and a discussion of the reasons cesarean delivery is so prevalent.

Michael Diamond, M.D., Joins Scientific Advisory Board

We are proud to announce the addition of Michael Diamond, M.D., to the ZSX Medical scientific advisory board. Dr. Diamond is a professor of obstetrics and gynecology at Wayne State University, and a practicing gynecologist. Dr. Diamond is a world-renowned expert in soft tissue adhesions, and has taken part in the clinical development of virtually every anti-adhesion product to reach the market. As a member of our scientific advisory board, Dr. Diamond participates in all aspects of ZSX Medical's product development strategy, including clinical and pre-clinical trial design.

ZSX Medical to Present at AdvaMed 2010
ZSX Medical is honored to be one of a select group of companies to present at AdvaMed 2010.

Held from October 18th to 20th at the Walter E. Washington Convention Center in Washington D.C., AdvaMed 2010 is the premier MedTech Conference for CEOs, business executives, policy-makers, financiers, media, and industry stakeholders from around the world. It provides the opportunity to network with more than 1,500 key MedTech executives from companies in every sector of the industry. If you will be attending AdvaMed, please let us know, so that we can make time to meet with you. And don't miss our conference talk at 9:10 AM on Tuesday morning, October 19. For more details about this conference, you can visit www.advamed2010.com.

ZSX to Present at the Inaugural IMPACT 2010
ZSX Medical is also honored to present at the inaugural IMPACT.

IMPACT 2010 is an event organized by the Greater Philadelphia Alliance for Capital and Technologies (PACT). It will be held on November 9 & 10 at the Pennsylvania Convention Center and the Crystal Tea Room. This one and a half day event provides a great opportunity to engage with topical speakers and keep abreast with developments of companies through their presentations. Be sure to catch us there and you can visit www.philadelphiapact.com/impact2010.html for more information.

Cesarean Delivery: A Rising Trend

Continuing in our series of issues in obstetric surgery, we present reasons for the ongoing dramatic rise in cesarean delivery.  Cesarean delivery has traditionally been performed when vaginal delivery poses a risk to the health or life of the baby or mother. For example, if labor is taking too long, and the baby is showing signs of distress, there may be a risk to the baby. Alternatively, if the baby is too large for the birth canal or is in a poor position for delivery, there is a risk to the mother. Or the mother may simply have had a previous cesarean delivery, and the medical team may be concerned that the uterus hasn’t healed adequately to deliver vaginally.1

These and other reasons have made cesarean delivery the most common large incision surgery, both in the U.S. and worldwide. According to the Centers for Disease Control, cesarean deliveries represented almost one third of the more than 4 million births in the U.S. in 2007. Overall, cesarean delivery has grown much faster than the birth rate over the past decade. Thus, the fraction of deliveries by cesarean has been growing, from one in five in 1996 to its current status of almost one in three.2

Why are Cesarean Delivery Rates Rising?

Many factors contribute to this growth. One reason is the increased age of first-time mothers. In the U.S., 40 times more women are having first babies after age 40 today versus thirty years ago. Older first-time mothers are far more likely to undergo cesarean delivery than younger moms. Another reason for the increase in cesarean deliveries is the decline of vaginal birth after cesarean (VBAC). Fifteen years ago, almost 30% of deliveries after cesarean were by VBAC; today, well below 10% of deliveries are. Finally, obesity contributes to the increasing cesarean delivery rate. Obesity in the U.S. doubled in the 10 year period from 1991 to 2001,3 so that by 2006, more than a third of U.S. women qualified as obese.4  Obese mothers are more prone to having large babies, gestational diabetes, and high blood pressure, all of which can necessitate cesarean delivery.5

Global Outlook of Cesarean Delivery

There are ten times as many cesarean deliveries outside the U.S. as inside. Although some reasons for worldwide prevalence of cesarean delivery match those in the U.S., there are also regional cultural attitudes that have favored the growth of cesarean delivery in specific countries. Specifically, in China, the largest single reason for the growth of cesarean delivery has been maternal request, rather than medical necessity.6 Figure 2 shows the four countries with the most cesarean deliveries.

Implications for ZSX Medical

Certainly cesarean delivery is not going away. We will always need to deliver babies surgically, and we will always need to make an incision large enough for the baby’s head. ZSX Medical sees it as our responsibility to reduce the impact of surgery on both mother and child.

Keeping in Touch
Thank you for reading our newsletter. ZSX Medical is reachable through www.zsxmedical.com or www.ZipStitch.com. In addition to this newsletter, we may use our site periodically as a mechanism to keep interested parties informed as to our progress. Check back often!

Dan Mazzucco, President & CTO
Eric Rugart, COO


  1. Cesarean Birth. Jan. 2005. The American College of Obstetricians and Gynecologist. 24 Sept 2010 <http://www.acog.org/publications/patient_education/bp006.cfm>
  2. Hamilton BE, Menacker F. Recent Trends in Cesarean Delivery in the United States. National vital statistics reports; Data Brief no 35. Hyattsville, MD. National Center for Health Statistics, Released March 2010. Available from: http://www.cdc.gov/nchs/data/databriefs/db35.pdf
  3. Mokdad AH, Serdula MK, Dietz WH, Bowman B, Marks JS, Koplan JP. The spread of the obesity epidemic in the United States, 1991–1998. JAMA 2000;284:1650 
  4. Obesity and Overweight. Sept. 2006. World Health Organization. 24 Sept 2010 <http://www.who.int/mediacentre/factsheets/fs311/en/index.html>.
  5. Fisher J.J, Frey I. Pregnany and Parturition in the Obese Patient. Obstetrics and gynecology. 1958;11(1):92-94.
  6. Zhang J, Liu Y, Meikle S, Zheng J, Sun W, Li Z. Cesarean delivery on maternal request in southeast China. Obstetrics and gynecology. 2008;111(5):1077-1082.

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