ZSX 4th Quarter 2009 Newsletter

ZSX Medical Quarterly Newsletter
December 2009


Welcome to the ZSX Medical newsletter for the fourth quarter of 2009. We are sending this newsletter to those who have requested to be updated as to our company's progress. In this newsletter, we will briefly outline what we have accomplished in the last quarter, and give a brief non-medical primer on post-operative adhesions.

Who We Are
For those who are new to our company, ZSX is short for "Zip-Stitch® Surgical Access and Closure Systems." The name Zip-Stitch® conveys both the ease of use and the speed of closure of the product we are developing for cesarean delivery; but ZSX Medical is doing far more than developing a product. Our mission is to reinvent uterine closure in cesarean delivery.

Recent News
1. ZSX Medical has determined a three-phase pathway to establish proof-of-concept for Zip-Stitch®. In this quarter, ZSX Medical completed Phase I of proof-of concept testing. Completion of this first phase marks a major milestone for our company.

2. ZSX Medical has initiated an in vivo pre-clinical study as Phase II of the proof-of-concept pathway. We are proud to partner with Drexel University College of Medicine in this work.

Why Post-Operative Adhesions Matter
In addition to keeping you informed as to what we're doing, we want to take some time in our newsletter to remind you why we're doing it. Cesarean delivery is a great procedure, in that it saves the lives of millions of babies and mothers every year. Nonetheless, cesarean delivery is major surgery, and it has significant complications. We are committed to help reducing these complications, to help speed the recovery of the many mothers who deliver by this method.

In this issue, we are highlighting post-operative adhesions, which are one category of complication that we are trying to address. Adhesions are the medical term for scar tissue; adhesions often occur at locations of internal wound healing, such as after surgery. Adhesions are very common; in abdominal surgery, reports of adhesion rates can range from 57%1 to as high as 91%.2 If you've had arm or leg surgery, you may be familiar with adhesions because a physical therapist may have helped you do exercises to break up adhesions. If you did not break up the scar tissue, it might affect your range of motion.

For other internal surgeries, such as cesarean delivery, there aren't exercises that you can do to break up adhesions. Adhesions often form as a result of a cesarean delivery, so they are often seen at repeat cesarean delivery. They become more common and thicker as the number of cesarean deliveries increases.3 Fortunately, most of the time, patients don't notice these adhesions, because your internal organs don't have to move around the way your arms and legs do. But when they do cause problems, these problems can be very bad. Adhesions can cause persistent pain, they can lead to difficulty getting pregnant, and can cause life-threatening digestive problems.

Even when the patient doesn't notice adhesions, they can cause her problems. A first time cesarean delivery takes about 30 minutes. But during second cesarean delivery, if there are adhesions present, it takes the doctor an extra five minutes to cut through the adhesions to get to the baby. In a third cesarean delivery, it takes ten minutes to cut through the adhesions.3 If you have to have surgery, you want to keep it as brief as possible, because the longer the procedure takes, the longer you need to be under anesthesia, the more blood you lose, and the greater your risk for getting an infection.

In summary, gynecological adhesions (that is, scar tissue on the female reproductive tract) are a serious problem. ZSX Medical is committed to developing products to prevent adhesions from forming. We see that a lot of women deliver babies by cesarean section every year, and we see a great opportunity to help these women have a simpler and safer procedure.

Keeping in Touch
ZSX Medical is reachable through www.ZSXMedical.com or www.ZipStitch.com. We are also listed on YouNoodle.com. In addition to this newsletter, we may use our site periodically as a mechanism to keep interested parties informed as to our progress. Check back often!

Dan Mazzucco, President & CTO
Eric Rugart, COO

For more information regarding Zip-Stitch®, email us at info@zsxmedical.com

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  1. Saravelos H, Li TC. Post-operative adhesions after laparoscopic electrosurgical treatment for polycystic ovarian syndrome with the application of Interceed to one ovary: a prospective randomized controlled study. Human reproduction (Oxford, England). 1996;11(5):992-997.
  2. Duron JJ, Olivier L. Foreign bodies and intraperitoneal post-operative adhesions. Journal of long-term effects of medical implants. 1997;7(3-4):235-242.
  3. Tulandi T, Agdi M, Zarei A, Miner L, Sikirica V. Adhesion development and morbidity after repeat cesarean delivery. American journal of obstetrics and gynecology. 2009;201(1):56 e51-56.


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